產品櫥窗
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Kaurenoic acid, >98%
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產品型號：101-6730-83-2 商品規格： |
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Ent-kaurenoic acid, Kaur-16-en-18-oic acid, Kauren-19-oic acid, Kaurenic acid, Cunabic acid
Formular: C20H30O2
MW: 302.45
Description:
Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti- inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects
Applications：
. Kaurenoic acid exhibits potent anti-inflammatory activity by modulating key inflammatory pathways, including inhibition of NF-κB. It suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-33) while enhancing anti-inflammatory cytokine IL-10. It also reduces leukocyte migration and inhibits histamine and serotonin pathways .
. It shows selective antibacterial activity against Gram-positive bacteria, as well as activity against certain Gram-negative and mycobacteria species. Its amphipathic nature allows interaction with phospholipid bilayers, supporting its antibacterial mechanism .
. Kaurenoic acid has demonstrated selective cytotoxic effects against cancer cell lines. It has been studied for potential applications in breast cancer, lung cancer, melanoma, and cervical cancer, with research indicating effects on cell cycle progression and genotoxicity .
. Intraperitoneal administration in hyperglycemic rat models showed a potent and prolonged hypoglycemic effect, comparable or superior to standard drugs like glibenclamide and glimepiride .
. It induces uterine relaxation via calcium channel blockade and opening of ATP-sensitive potassium channels, suggesting potential applications in gynecological research .
. It exhibits activity against Trypanosoma cruzi (Chagas disease) and Leishmania amazonensis, targeting acidocalcisomes in the parasites .
MW: 302.45
Description:
Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti- inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects
Applications：
. Kaurenoic acid exhibits potent anti-inflammatory activity by modulating key inflammatory pathways, including inhibition of NF-κB. It suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-33) while enhancing anti-inflammatory cytokine IL-10. It also reduces leukocyte migration and inhibits histamine and serotonin pathways .
. It shows selective antibacterial activity against Gram-positive bacteria, as well as activity against certain Gram-negative and mycobacteria species. Its amphipathic nature allows interaction with phospholipid bilayers, supporting its antibacterial mechanism .
. Kaurenoic acid has demonstrated selective cytotoxic effects against cancer cell lines. It has been studied for potential applications in breast cancer, lung cancer, melanoma, and cervical cancer, with research indicating effects on cell cycle progression and genotoxicity .
. Intraperitoneal administration in hyperglycemic rat models showed a potent and prolonged hypoglycemic effect, comparable or superior to standard drugs like glibenclamide and glimepiride .
. It induces uterine relaxation via calcium channel blockade and opening of ATP-sensitive potassium channels, suggesting potential applications in gynecological research .
. It exhibits activity against Trypanosoma cruzi (Chagas disease) and Leishmania amazonensis, targeting acidocalcisomes in the parasites .
Store at Room Temp.