產品櫥窗
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Shield-1
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產品型號：101-914805-33-7 商品規格： |
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Shield 1, an AKT inhibitor, potently inhibits proliferation as well as induces apoptosis in prostate cancer cell lines.
Formula：C42H56N2O10
M.W.: 748.90
Solubility: DMSO: ≥ 250 mg/mL (333.82 mM)
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).
Shield-1 (0.1 nM-1 μM) responses characterization of destabilizing domains. Shield-1 (1 μM; 24 h) treatment shows excellent expression on both TRPV5 and YFP when fused the mtFKBP destabilizing domain to either TRPV5 or YFP, and leads to mtFKBP-TRPV5 forming a functional ion channel.
M.W.: 748.90
Solubility: DMSO: ≥ 250 mg/mL (333.82 mM)
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).
Shield-1 (0.1 nM-1 μM) responses characterization of destabilizing domains. Shield-1 (1 μM; 24 h) treatment shows excellent expression on both TRPV5 and YFP when fused the mtFKBP destabilizing domain to either TRPV5 or YFP, and leads to mtFKBP-TRPV5 forming a functional ion channel.
Store at 4℃.
For long term storage at -20℃
For long term storage at -20℃