產品櫥窗
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IBMX
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產品型號：101-28822-58-4 商品規格： |
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IBMX, >99%, Non-specific inhibitor of cAMP and cGMP phosphodiesterases. Synonym: 3-Isobutyl-1-methylxanthine, 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
CAS#28822-58-4
C10H14N4O2
MW: 222.3
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
Solubility: Soluble in DMSO (~6mg/ml), Methanol, DMF, or 100% Ethanol
C10H14N4O2
MW: 222.3
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
Solubility: Soluble in DMSO (~6mg/ml), Methanol, DMF, or 100% Ethanol
Recommends storing IBMX at -20°C. IBMX is also considered stable at room temperature.